Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?
Identifieur interne : 000209 ( Main/Exploration ); précédent : 000208; suivant : 000210Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?
Auteurs : Xiang-Nan Yu [République populaire de Chine] ; Hong Chen [République populaire de Chine] ; Tao-Tao Liu [République populaire de Chine] ; Jian Wu [République populaire de Chine] ; Ji-Min Zhu [République populaire de Chine] ; Xi-Zhong Shen [République populaire de Chine]Source :
- Biochimica et biophysica acta. Reviews on cancer [ 1879-2561 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Carcinome hépatocellulaire, Sérine-thréonine kinases TOR, Tumeurs du foie.
- physiologie : Transduction du signal.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : TOR Serine-Threonine Kinases.
- metabolism : Carcinoma, Hepatocellular, Liver Neoplasms.
- physiology : Signal Transduction.
- Animals, Humans.
Abstract
The mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a therapeutic target, and explores clinical trials targeting the mTOR pathway in HCC. Although the review focuses on the mTOR pathway involved in HCC, more comprehensive discussions (eg, developing a rational design for future trials targeting the mTOR pathway) are also applicable to other tumors.
DOI: 10.1016/j.bbcan.2019.03.001
PubMed: 30951815
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: zhu.jimin@zs-hospital.sh.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Xi Zhong" sort="Shen, Xi Zhong" uniqKey="Shen X" first="Xi-Zhong" last="Shen">Xi-Zhong Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address: shen.xizhong@zs-hospital.sh.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta. Reviews on cancer</title><idno type="eISSN">1879-2561</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Carcinoma, Hepatocellular (metabolism)</term><term>Humans (MeSH)</term><term>Liver Neoplasms (metabolism)</term><term>Signal Transduction (physiology)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Carcinome hépatocellulaire (métabolisme)</term><term>Humains (MeSH)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal (physiologie)</term><term>Tumeurs du foie (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Sérine-thréonine kinases TOR</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a therapeutic target, and explores clinical trials targeting the mTOR pathway in HCC. Although the review focuses on the mTOR pathway involved in HCC, more comprehensive discussions (eg, developing a rational design for future trials targeting the mTOR pathway) are also applicable to other tumors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30951815</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-2561</ISSN><JournalIssue CitedMedium="Internet"><Volume>1871</Volume><Issue>2</Issue><PubDate><Year>2019</Year><Month>04</Month></PubDate></JournalIssue><Title>Biochimica et biophysica acta. Reviews on cancer</Title><ISOAbbreviation>Biochim Biophys Acta Rev Cancer</ISOAbbreviation></Journal><ArticleTitle>Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?</ArticleTitle><Pagination><MedlinePgn>379-391</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0304-419X(18)30211-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbcan.2019.03.001</ELocationID><Abstract><AbstractText>The mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a therapeutic target, and explores clinical trials targeting the mTOR pathway in HCC. Although the review focuses on the mTOR pathway involved in HCC, more comprehensive discussions (eg, developing a rational design for future trials targeting the mTOR pathway) are also applicable to other tumors.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Xiang-Nan</ForeName><Initials>XN</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Zhongshan Hospital of Fudan University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Tao-Tao</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Ji-Min</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China. Electronic address: zhu.jimin@zs-hospital.sh.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Xi-Zhong</ForeName><Initials>XZ</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address: shen.xizhong@zs-hospital.sh.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>04</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta Rev Cancer</MedlineTA><NlmUniqueID>9806362</NlmUniqueID><ISSNLinking>0304-419X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006528" MajorTopicYN="N">Carcinoma, Hepatocellular</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Cellular function</Keyword><Keyword MajorTopicYN="Y">Hepatocellular carcinoma</Keyword><Keyword MajorTopicYN="Y">Non-coding RNAs</Keyword><Keyword MajorTopicYN="Y">The mTOR pathway</Keyword><Keyword MajorTopicYN="Y">Therapeutic target</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30951815</ArticleId><ArticleId IdType="pii">S0304-419X(18)30211-7</ArticleId><ArticleId IdType="doi">10.1016/j.bbcan.2019.03.001</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yu, Xiang Nan" sort="Yu, Xiang Nan" uniqKey="Yu X" first="Xiang-Nan" last="Yu">Xiang-Nan Yu</name></noRegion><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Liu, Tao Tao" sort="Liu, Tao Tao" uniqKey="Liu T" first="Tao-Tao" last="Liu">Tao-Tao Liu</name><name sortKey="Shen, Xi Zhong" sort="Shen, Xi Zhong" uniqKey="Shen X" first="Xi-Zhong" last="Shen">Xi-Zhong Shen</name><name sortKey="Wu, Jian" sort="Wu, Jian" uniqKey="Wu J" first="Jian" last="Wu">Jian Wu</name><name sortKey="Zhu, Ji Min" sort="Zhu, Ji Min" uniqKey="Zhu J" first="Ji-Min" last="Zhu">Ji-Min Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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